Zantac Research Today is a free monthly online journal that collates and summarizes the latest research about Zantac, including details on ranitidine, side-effects, allergic reactions, information.

Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats.

Tanda S, Mori Y, Kimura T, Sonomura K, Kusaba T, Kishimoto N, Kameyama H, Tamagaki K, Okigaki M, Hatta T, Sasaki S, Takeda K, Sado Y, Adachi N, Matsubara H

Division of Cardiology and Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kawaramachi Hirokoji, Kyoto 602-8566, Japan. standa@koto.kpu-m.ac.jp

Anti-glomerular basement membrane (anti-GBM)-induced glomerulonephritis involves T-helper type 1 (Th1) responses leading to rapid crescent formation. As many inflammatory and immune responses in general are affected by histamine, we examined the effects of histaminergic ligands on immune renal injury in the rat. Female Wistar-Kyoto rats were injected intraperitoneally with an antibody against the GBMs. Histaminergic ligands were then injected twice daily for 5 days after which renal function was assessed by proteinuria. Treatment with histamine led to significant dose-dependent reductions in proteinuria compared to the control antibody-injected group and markedly decreased the number of crescentic glomeruli and macrophage infiltration of the glomeruli. Furthermore, histamine significantly decreased the plasma concentration of interleukin-12, a Th1-type cytokine compared to the antibody-injected control animals. Dimaprit, an H(2)/H(4) agonist, mimicked the effects of histamine on proteinuria and crescent formation. Clozapine, an H(4) agonist, tended to mimic the effects of histamine, whereas an H(1), mepyramine, or an H(2) antagonist, ranitidine, did not reverse the protective effect of histamine. We suggest that histamine may alleviate renal injury in anti-GBM glomerulonephritis by suppressing the immune response.

Published 23 August 2007 in Kidney Int, 72(5): 608-13.
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