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Gastroprotective effect of swallow root (Decalepis hamiltonii) extract: possible involvement of H(+)-K(+)-ATPase inhibition and antioxidative mechanism.

Naik Y, Jayaram S, Harish Nayaka MA, Lakshman , Dharmesh SM

Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570020, Karnataka, India.

The present study reports the antiulcer potentials of aqueous extract of swallow root (Decalepis hamiltonii Wight & Arn, SRAE) belonging to the family Asclepiadaceae. Swim stress-induced ulcers with an ulcer index (UI) of 6.0+/-0.01 was protected up to 43% and 72% at 100 and 200mg/kg b.w. of SRAE, respectively, similar to protection offered by ranitidine (79%) at 30mg/kg b.w. Depletion in antioxidant enzymes and increased Thiobarbituric Acid Reactive Substances (TBARS) were observed in ulcer-induced rats while SRAE fed rats showed normal levels. SRAE also normalized approximately 3.1 and 2.4 folds of increased H(+)-K(+)-ATPase and gastric mucin, respectively, in ulcerous animals, similar to the levels found in healthy controls. SRAE also possessed reducing power, free radical scavenging ability with an IC(50) of 0.17microg/mL gallic acid equivalent (GAE), comparable to that of BHA (IC(50)-0.08microg/mL). DNA protection up to 80% at 0.2microg was also observed. Toxicity studies indicated no lethal effects in rats fed up to 5g/kg b.w. Antioxidant, proton pump inhibition as well as boosting of gastric mucin effects of SRAE have been implicated to be responsible for antiulcer property of SRAE.

Published 14 May 2007 in J Ethnopharmacol, 112(1): 173-9.
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