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Cellulose acetate/chitosan multimicrospheres preparation and ranitidine hydrochloride release in vitro.

Zhou HY, Chen XG, Liu CS, Meng XH, Liu CG, He J, Yu le J

College of Marine Life Science, Ocean University of China, Qingdao, PR, China.

A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. The optimal condition for preparation of the microspheres was CA concentration at 2% and the ratio of CA/CS at 3/1. The microspheres size was 200-350 microm. The appearance of microspheres was spherical, porous, and nonaggregated. The highest loading efficiency was 21%. The ranitidine release from the CACM was 40% during 48 hr in buffers.

Published 12 June 2006 in Drug Deliv, 13(4): 261-7.
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